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为观察叶下珠提取物对四氯化碳和Ｄ半乳糖胺诱发小鼠急性肝损伤的防治作用，使用不同剂量叶下珠给小鼠胃饲。结果发现给予生药１０ｇ／（ｋｇ·ｄ）和５ｇ／（ｋｇ·ｄ）时叶下珠均可明显降低由四氯化碳引起的小鼠ＡＬＴ的升高（Ｐ＜００５）。且观察了大剂量组小鼠肝脏的形态变化，发现给药组坏死灶数目明显减少，肝细胞变化亦较轻。通过肝细胞坏死灶面积测量，计算坏死灶抑制率为４６１％。对Ｄ半乳糖胺引起肝损伤的防治作用在给予生药１０ｇ／（ｋｇ·ｄ）时表现明显，５ｇ／（ｋｇ·ｄ）时几乎无效。在肝脏损伤后给予生药１０ｇ／（ｋｇ·ｄ）组也观察到一定治疗效果。提示叶下珠对化学性肝损伤具有较好保护作用。
To observe the Phyllanthus extract on carbon tetrachloride and D galactosamine induced acute liver injury in mice, the use of different doses of Phyllanthus to stomach feeding. It was found that Phyllanthus administered with 10g / (kg · d) and 5g / (kg · d) of crude drugs significantly decreased the ALT level in mice induced by carbon tetrachloride (P <005). The morphological changes in the liver of the high-dose group were observed. The number of necrotic lesions in the treated group was significantly reduced, and the change in the hepatocytes was also lighter. Through the area of necrosis of liver cells, the inhibition rate of necrosis was calculated to be 46.1%. D-galactosamine-induced liver injury prevention and treatment given crude drug 10g / (kg · d) when the obvious performance, 5g / (kg · d) almost ineffective. After liver injury given crude drug 10g / (kg · d) group also observed a certain therapeutic effect. Tip Phyllanthus has a good protective effect of chemical liver injury.