论文部分内容阅读
目的:观察补肾化瘀汤联合米非司酮治疗卵巢子宫内膜异位症的临床疗效.方法:收集2014年6月至2016年6月就诊于本院的卵巢子宫内膜异位症患者,采用随机数字表法将符合纳入标准的患者随机分为两组,每组各40例.对照组给予口服米非司酮治疗,试验组在此基础上加用补肾化瘀汤,两组疗程均为3个月,观察两组患者症状改善情况、盆腔包块大小变化、血清免疫学指标含量及安全性指标变化.结果:试验过程中试验组脱落1例,治疗后,试验组临床总有效率为94.87％,与对照组有效率(75.00％)比较,差异有统计学意义(P＜0.05);月经周期同 时期盆腔包块大小比较,治疗后组间比较,治疗组患者盆腔包块较对照组明显缩小,差异有统计学意义(P＜0.05);两组患者在降低CA125方面差异无统计学意义(P＞0.05),试验组在降低患者血清中TNF-a含量方面明显优于对照组(P＜0.05);治疗后,试验组患者EMAB转阴率为69.23％,对照组为40.00％,差异具有统计学意义(P＜0.05);两组治疗前后血尿便常规、肝肾功能、心电图等各项安全检查均未见异常改变.结论:补肾化瘀汤联合米非司酮可明显改善卵巢子宫内膜异位症患者的临床症状,缩小患者盆腔包块大小,降低肿瘤相关免疫学指标,且对肝肾功能无明显损害,值得在临床广泛应用和推广.“,”Objective:To observe the effectiveness of Bushen Huayu Decoction combined mifepristone on ovarian endometriosis.Methods:From June 2014to June 2016,we collected 80patients which had got ovarian endometriosis,then the 80patients were randomly divided into experimental group and controlled group,each group had 40people.The controlled group received conventional mifepristone,the experimental group received Bushen Huayu Decoction on the basis of this for 3months.We observed the changes of symptom scores,pelvic mass size,serum immunology index content and safety indices before and after treatment.Results:The experimental group fall off in one case,so it had 39cases and the controlled group had 40cases at last.After treatment,the total effective rate of the treatment group was 94.87％,the group effective rate of the controlled was 75.00％,the difference was statistically significant (P＜0.05).Compared with controlled group,the treatment group patients with pelvic mass narrowed considerably (P＜0.05).In the two groups after treatment in patients with serum CA1251evels were lower,but there was no statistically significant difference (P＞0.05).In patients with lower serum TNF-a content aspect,the treatment group was better than the controlled group (P＜0.05).After treatment,the treatment group patients EMAB overcast rate was 69.23％,the controlled group was 40.00％,the difference was statistically significant (P＜0.05).Conclusion:Combining Bushen Huayu Decoction and mifepristone can significantly improve the clinical symptoms of patients with ovarian endometriosis,narrow pelvic bag piece size,reduce tumor related immunological indexes,and no damage to the liver and kidney function,worthy of application and promotion in clinical.