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作者报道54例服用乙胺碘呋酮的患者29例出现神经系统毒性作用。54例中男47、女7例,平均年龄60.2±15岁.因患室性心动过速或心室纤颤服乙胺碘呋酮治疗,开始剂量为800mg/d,口服,6～8周后减量为600mg/d,以后再根据病情减量维持,平均长期维持量为580±100mg/d.其中38例并用普鲁卡因酰胺、奎尼丁或心得安。平均随访时间为11.2±9.5个月。结果29例出现神经系统毒性作用。出现神经系统症状的时间为:于服药后1周内出现者占41%,1周～1个月占11%,1～4个月占26%,4个月后占22%。出现症状时乙
The authors reported the toxicity of neurotoxicity in 29 of 54 patients taking amiodarone. 54 cases of 47 males and 7 females, mean age 60.2 ± 15 years old due to suffering from ventricular tachycardia or ventricular fibrillation with amiodarone treatment, the initial dose of 800mg / d, orally, 6 to 8 weeks Reduction of 600mg / d, then reduce the disease according to maintain the average long-term maintenance of 580 ± 100mg / d, of which 38 cases with procainamide, quinidine or propranolol. The average follow-up time was 11.2 ± 9.5 months. Results 29 cases of nervous system toxicity. Neurological symptoms occurred in 41% of patients within 1 week, 1 week to 1 month 11%, 1 to 4 months 26%, and 4 months 22%. When symptoms occur