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目的:探究头孢曲松钠与解毒开窍汤联用对急性细菌性脑膜炎患者意识恢复及其预后的影响。方法:选取2014年9月—2016年5月间收治的急性细菌性脑膜炎患者73例,按入院顺序分组法将其分为对照组36例和治疗组37例;对照组患者给予单用头孢曲松钠治疗,治疗组患者在对照组基础上加用自拟解毒开窍汤治疗,评价两组患者持续治疗1周后和治疗前后C反应蛋白(CRP)、肿瘤坏死因子-α(TNF-α)测得值的变化情况以及意识复常时间及预后情况。结果:两组患者治疗前CRP、TNF-α测得值经组间比较其差异无统计学意义(P>0.05);治疗组患者治疗后CRP、TNF-α测得值均明显低于对照组(P<0.05),意识复常时间为(3.91±0.42)d明显优于对照组为(5.23±0.48)d(P<0.05),治疗3月后并发症的总发生率为2.70%稍低于对照组为8.33%,经组间比较其差异无统计学意义(P>0.05)。结论:采用头孢曲松钠与自拟解毒开窍汤治疗急性细菌性脑膜炎患者,可有效缩短患者意识复常时间及其改善其预后。
Objective: To investigate the effect of combination of ceftriaxone sodium and detoxification and resuscitation on consciousness recovery and prognosis in patients with acute bacterial meningitis. Methods: Seventy-three patients with acute bacterial meningitis admitted from September 2014 to May 2016 were divided into control group (36 cases) and treatment group (37 cases) according to the order of hospitalization. Patients in the control group The treatment group was treated with detoxification Kaiqiao Decoction on the basis of the control group, and the levels of C-reactive protein (CRP), tumor necrosis factor-α (TNF-α ) Measured changes in the value and awareness of recurrent time and prognosis. Results: Before treatment, CRP and TNF-α in two groups had no significant difference after treatment (P> 0.05); the CRP and TNF-α in the treatment group were significantly lower than those in the control group (P <0.05). The time of consciousness recovery (3.91 ± 0.42) d was significantly better than that of control group (5.23 ± 0.48) d (P <0.05). The total complication rate after 3 months of treatment was 2.70% In the control group was 8.33%, no significant difference between the groups (P> 0.05). Conclusion: The use of ceftriaxone sodium and self-detoxification Kaiqiao decoction in patients with acute bacterial meningitis, can effectively shorten the patient awareness of recanalization time and improve their prognosis.