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目的:评价戊酸雌二醇与醋酸甲羟孕酮联用对围绝经期患者功能失调性子宫出血的疗效。方法:选取2015年1—12月间收治的围绝经期功能失调性子宫出血患者80例,按数字表抽取法将其随机分为对照组40例和观察组40例;对照组患者给予醋酸甲羟孕酮片治疗,观察组患者在对照组基础上加用戊酸雌二醇片治疗,比较两组患者治疗后的总有效率和止血的效果。结果:观察组患者治疗后控制出血时间和完全止血所需时间均短于对照组(P<0.05),总有效率为97.50%高于对照组为75.00%(P<0.05);两组患者用药期间不良反应的发生率低于对照组(P<0.05)。结论:针对临床收治的围绝经期功能失调性子宫出血患者,采用戊酸雌二醇片与醋酸甲羟孕酮片治疗,安全性高,出血时间短,复发率低。
Objective: To evaluate the efficacy of estradiol valerate combined with medroxyprogesterone acetate in patients with dysfunctional uterine bleeding during perimenopausal period. Methods: Eighty patients with peri-menopausal dysfunctional uterine bleeding who were admitted from January to December in 2015 were randomly divided into control group (n = 40) and observation group (n = 40) according to digital table extraction method. Patients in control group Hydroxyprogesterone tablets were treated in the observation group. The patients in the observation group were treated with estradiol valerate on the basis of the control group. The total effective rate and the effect of stopping bleeding were compared between the two groups after treatment. Results: The time of hemorrhage control and complete hemostasis in observation group were shorter than that in control group (P <0.05), the total effective rate was 97.50%, which was 75.00% (P <0.05) in control group. During the adverse reaction rate was lower than the control group (P <0.05). Conclusion: For the clinical treatment of peri-menopausal dysfunctional uterine bleeding patients, the use of estradiol valerate tablets and medroxyprogesterone acetate tablets treatment, high safety, short bleeding time, low recurrence rate.