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目的:探讨抑肽酶致过敏性休克的规律与特点,为临床合理用药提供参考。方法:检索国内医药数据库,下载原始病例报告进行统计与分析。结果:抑肽酶致过敏性休克与患者性别、给药途径与剂量等无关;以速发型(30 min以内发生者占84.3%)为主,缓发型仅占3.9%;皮肤过敏试验过程中也可以发生;外科手术麻醉期间发生过敏性休克者报告较多(34例);临床表现以循环系统、中枢神经系统和呼吸系统症状为主。经积极的抗过敏性休克抢救,46例恢复正常,5例死亡。结论:坚持合理用药是预防抑肽酶发生过敏性休克的有效措施。
Objective: To investigate the regularity and characteristics of aprotinin-induced shock and to provide a reference for clinical rational drug use. Methods: Retrieve the domestic medical database, download the original case report for statistics and analysis. Results: The aprotic shock induced by aprotinin was not related to the patient’s sex, route of administration and dosage, etc. The rapid onset type (84.3% in 30 min) was the predominant and the slow type was only 3.9%. The skin allergy test Can occur; surgical anaphylaxis occurred during anesthesia were reported more (34 cases); clinical manifestations of the circulatory system, the central nervous system and respiratory symptoms based. After active anti-atopic shock rescue, 46 cases returned to normal, 5 died. Conclusion: Adhering to the rational use of drugs is an effective measure to prevent anaphylactic shock of aprotinin.