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目的:探讨克林霉素致不良反应发生的规律及特点,为临床合理用药提供参考。方法:通过中国知网(CNKI)检索1999～2010年有关克林霉素致不良反应的有效文献205篇,对相关关键信息进行统计、分析。结果:收集克林霉素所致不良反应243例。不良反应以过敏性休克、肾功能损害及血尿最多;发生时间最早的在用药1min内,最迟在用药16 d后。给药途径以静滴为主,230例剂量范围0.15～1.8 g/次,4例剂量超过2.0 g/次。结论:克林霉素引起的不良反应临床表现复杂多样,其发生与多种因素有关,严重者可致死亡。
Objective: To investigate the regularity and characteristics of clindamycin-induced adverse reactions and to provide a reference for clinical rational drug use. Methods: The CNKI was used to search 205 valid articles about clindamycin-induced adverse reactions from 1999 to 2010. The related key information was statistically analyzed. Results: 243 cases of clindamycin-induced adverse reactions were collected. Adverse reactions to anaphylactic shock, renal dysfunction and hematuria up; the earliest occurred within 1min medication, at the latest after 16 days of medication. The main routes of administration were intravenous drip, with 230 doses ranging from 0.15 to 1.8 g / dose and 4 doses exceeding 2.0 g / dose. Conclusion: Clinical manifestations of adverse reactions caused by clindamycin are complex and diverse, and its occurrence is related to a variety of factors, and severe cases can cause death.