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1 1988年世界首次上市的新药 1988年有52个新化学物体(NCE_S)在世界首次上市,比1987年(58个)减少11％,其中日本14个,已连续六年名列首位,其次法国7个,意大利上市五个占第三位,瑞典与英国各4个,瑞士3个,中国、丹麦新西兰与美国各2个,西德、葡萄牙、比利时、印度、南斯拉夫、象牙海岸各1个。从药效来分析,上市最多的是心脑血管系统新药共20个(38.5％),其次是抗感染新药共11个(21.1％),作用于神经与精神的新药5个(9.6％),抗肿瘤药、消化系统与呼吸系统新药各3个(各占5.8％),抗组胺药2个(3.8％),其他新药5个(9.6％)。具体情况如下;
1 The first new drug listed in the world in 1988 In 1988, 52 new chemical substances (NCE_S) were listed in the world for the first time, a decrease of 11% over 1987 (58), of which 14 were from Japan, ranking the first place for six consecutive years, followed by France Seven in the world, five in the Italian market, four in Sweden and the United Kingdom, three in Switzerland, two each in China, Denmark and New Zealand and the United States, one each in West Germany, Portugal, Belgium, India, Yugoslavia and Ivory Coast. From the analysis of pharmacodynamics, the most listed ones are 20 (38.5%) of new drugs of cardiovascular and cerebrovascular system, followed by 11 (21.1%) of new anti-infective drugs, 5 (9.6%) of new drugs acting on nerves and spirits, Three new antineoplastic agents, five digestive and respiratory drugs each (5.8% each), two antihistamines (3.8%) and five other new drugs (9.6%). Details are as follows;