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为确定小儿清热止咳颗粒的药效分别进行了七组动物实验。结果表明：小儿清热止咳颗粒对大肠杆菌内毒素引起的家兔发热有显著抑制作用；体外对金葡球菌、乙链球菌、绿脓杆菌、大肠埃希氏菌、痢疾杆菌有明显抑制作用；对金葡球菌攻击小鼠无明显保护作用；能明显降低浓氨水所致小鼠咳嗽次数；能明显促进小鼠气管分泌酚红及促进大鼠排痰，对组胺引起离体豚鼠气管平滑肌痉挛有明显的解痉作用。
To determine the efficacy of pediatric heat-relieving cough particles, seven groups of animal experiments were conducted. The results showed that Xiaoli Qingre Zhi Zhi Granule could significantly inhibit the heat-induced fever induced by E. coli endotoxin in rabbits, and significantly inhibited Staphylococcus aureus, Streptococcus viridans, Pseudomonas aeruginosa, Escherichia coli and Shigella in vitro; Staphylococcus aureus attack mice no significant protective effect; can significantly reduce the concentration of ammonia-induced mice cough frequency; can significantly promote phenol red trachea secretion and promote sputum in rats, histamine caused guinea pig tracheal smooth muscle spasm Obvious spasm effect.