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目的:分析染发次数与骨髓增生异常综合征(MDS)患者的血清乳酸脱氢酶(LDH)值、染色体分型、国际预后积分系统(IPSS)评分、骨髓网硬蛋白定量间的相关性。方法:将我院108例初诊的MDS患者按染发剂使用次数分组,比较各组间LDH值、染色体分型、IPSS积分、网硬蛋白定量等指标的差异;分析观察指标与染发次数间的相关性。结果:108例MDS患者中,难治性贫血4例,难治性贫血伴环形铁粒细胞9例,难治性血细胞减少伴多系发育异常46例,难治性贫血伴原始细胞增多34例,MDS不能分类者8例,5q-者7例。不同染发组MDS患者间LDH值、IPSS积分、骨髓网硬蛋白定量、染色体核型的差异具有统计学意义(P<0.05),且与染发次数呈正相关。结论:染发剂的使用对MDS患者的预后具有一定影响。
OBJECTIVE: To analyze the relationship between the number of hair dyeing and the serum LDH, chromosome typing, IPSS score and bone marrow reticulin quantitation in patients with myelodysplastic syndrome (MDS). Methods: 108 cases of newly diagnosed MDS patients in our hospital were grouped according to the number of hair dye used. The differences of LDH value, chromosome type, IPSS score and quantitative expression of Reticulin between groups were compared. The correlation between the observed index and the number of hair dyeings was analyzed Sex. Results: In 108 patients with MDS, refractory anemia in 4 cases, refractory anemia with ferritin in 9 cases, refractory cytopenia with multiple lineage dysplasia in 46 cases, refractory anemia with primitive cells in 34 cases , MDS can not be classified in 8 cases, 5q- in 7 cases. LDH value, IPSS score, quantitative analysis of bone marrow nether protein and chromosome karyotype in MDS patients with different hair dye groups were statistically significant (P <0.05), and were positively correlated with the number of hair dyeings. Conclusion: The use of hair dye has a certain impact on the prognosis of patients with MDS.