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目的探讨检测血清降钙素原(PCT)在肝衰竭继发感染的诊断价值。方法检测20例门诊体检者(A组)、28例慢性肝炎(B组)、28例肝衰竭前期(C组)和66例肝衰竭(D组)患者治疗前后血清PCT、TBil、PT、WBC和超敏C反应蛋白(hsCRP)水平。D组分为D1组(有继发感染,48例)和D2组(无继发感染,18例);D1组又分为D1a组(好转,8例)、D1b组(加重,40例)。对结果进行统计分析。结果 A、B、C和D组治疗前的PCT阳性率值分别为0、14.3%、57.1%和72.7%,组间差异明显(P<0.05)。治疗前,C、D组PCT分别与TBil、PT呈正相关(P<0.05)。PCT、WBC和hsCRP在D1组和D2组、D1a组和D1b组之间均有统计学差异(P<0.05)。结论血清PCT检测有助于肝衰竭继发感染的早期诊断。
Objective To investigate the diagnostic value of serum procalcitonin (PCT) in secondary infection of liver failure. Methods The serum levels of PCT, TBil, PT, WBC in 20 outpatients (group A), 28 patients with chronic hepatitis B (group B), 28 patients with prehepatic failure (group C) and 66 patients with liver failure (group D) And high-sensitivity C-reactive protein (hsCRP) levels. D group was divided into D1 group (48 cases with secondary infection) and D2 group (without secondary infection, 18 cases); D1 group was further divided into D1a group (improvement, 8 cases), D1b group (40 cases) . Statistical analysis of the results. Results The positive rates of PCT before treatment in groups A, B, C and D were 0, 14.3%, 57.1% and 72.7%, respectively. There was significant difference between groups (P <0.05). Before treatment, PCT in group C and D were positively correlated with TBil and PT (P <0.05). PCT, WBC and hsCRP in D1 group and D2 group, D1a group and D1b group were statistically significant differences (P <0.05). Conclusions Serum PCT is helpful for the early diagnosis of secondary infection of liver failure.