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生物质来源的乳酸乙酯作为一种新型的绿色有机反应介质逐渐受到人们的关注.这一溶剂具有无毒、生物可降解、廉价易得、沸点高、同时对水和多数有机物的优秀互溶性等各种符合理想绿色介质的优点.近几年来,以乳酸乙酯为溶剂成功实现了包括Suzuki偶联反应、Glaser偶联反应以及各类具有生物活性杂环化合物的串联合成等反应.本文结合我们自己的研究工作和兴趣,系统综述了近年来以乳酸乙酯为反应介质的有机合成反应研究进展.
As a new green organic reaction medium, bio-sourced ethyl lactate has drawn more and more attention because of its non-toxicity, biodegradability, low-cost and high-boiling point, excellent solubility in water and most organic compounds Etc. In recent years, the successful synthesis of Suzuki coupling reaction, Glaser coupling reaction and various series of biologically active heterocyclic compounds with ethyl lactate as solvent has been achieved. Our own research work and interests, systematic review of recent years, ethyl lactate as the reaction medium organic synthesis reaction progress.