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该文通过对70例幽门螺杆菌（HP）阳性的十二指肠溃疡患者，应用阿莫西林加洛赛克联合治疗，疗程两周，与单用洛赛克治疗组对比观察，结果：2周内溃疡愈合率（89.5％），优于单用洛赛克治疗组（P＜0．01），1年溃疡复发率（10．5％），明显优于单用洛赛克范疗组（P＜0．001），4周及1年HP根除率明显优于单用洛赛克治疗组（均P＜0．001）。但治疗期间临床症状缓解情况两组无明显差异（P＞0．05）。说明抗生素与抗酸剂合用，能明显提高HP根除率及降低近期溃疡复发率，疗程短，治疗方便，且无明显毒副作用，值得临床推广应用。
In this paper, 70 cases of Helicobacter pylori (HP) -related duodenal ulcer patients, the application of amoxicillin plus Losec combined treatment for two weeks, compared with the single Losec treatment group, the results: 2 The healing rate of ulcer in week was 89.5%, which was better than that of single Losec group (P <0.01) and the one-year ulcer group (10.5%), which was significantly better than that of single Losec group (P <0.001). HP eradication rates at 4 weeks and 1 year were significantly better than those treated with Losec alone (all P <0.001). However, there was no significant difference between the two groups in clinical symptom relief during treatment (P> 0.05). Description of antibiotics combined with antacids, can significantly improve the HP eradication rate and reduce the incidence of recent ulcer recurrence, short course, easy to treat, and no obvious side effects, it is worthy of clinical application.