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目前国内外均有黑热病疫情回升的报道。我国近年六个省(区)仍有不少病人。四川西部和甘肃文县等地均有较大幅度的回升,主要传染源为病犬,犬的感染率高达15％,且黑热病患者用锑剂治疗后复发率高。因而对本病的预防具有重要的意义。用具有保护性的单克隆抗体去研究它所识别的虫体抗原的分布和性质,了解保护作用的机制,对分离纯化这些保护性抗原等具有理论意义和实用价值。
There are reports of a rise in the epidemic of kala-azar both at home and abroad. In recent years, there are still many patients in six provinces (districts) in our country. The western Sichuan and Gansu Wenxian and other places have a more substantial recovery, the main source of infection for dogs, dog infection rate as high as 15%, and the patients with kala azar treatment after treatment with high recurrence rate. Therefore, the prevention of this disease is of great significance. It is of theoretical significance and practical value to isolate and purify these protective antigens using the protective monoclonal antibody to study the distribution and properties of the antigen recognized by the parasites and to understand the mechanism of protection.