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目的:探讨非小细胞肺癌(non-small cell lung carcinoma,NSCLC)组织中Foxp3+调节性T细胞(regulatory T cell,Treg)与18F-脱氧葡萄糖(fluorodeoxyglucose,FDG)PET/CT原发灶最大标准摄取值(maximum standardized uptake value,SUVmax)的相关性及其对临床预后的影响。方法:收集2008年3月至2014年10月天津医科大学肿瘤医院收治的122例原发性NSCLC患者的临床、影像、病理、组织标本及随访资料。采用免疫组化法检测肺癌组织中Treg浸润情况。采用Kaplan-Meier法分析患者生存情况,并分析Treg浸润情况与原发灶SUVmax的相关性,及与各临床病理因素的关系。结果:Treg浸润情况与原发灶SUVmax呈正相关(r=0.291,P=0.001)。Treg及SUVmax均以临界值(cut off)值分高低两组,单因素分析显示Treg、SUVmax是影响患者预后的危险因素;临床资料分析显示,肿瘤越大、肿瘤分期越高,Treg浸润越严重(P<0.05)。Cox多因素分析显示肿瘤TNM分期(HR=7.537,95%CI:1.191-2.855,P=0.006)为患者生存的独立预后影响因子。结论:NSCLC组织中Treg浸润与PET/CT SUVmax正相关,PET/CT SUVmax可提示NSCLC患者肿瘤微环境中Treg浸润情况,对判断患者临床预后及临床用药有一定的指导作用。
Objective: To investigate the maximum standard intake of Foxp3 + regulatory T cells (Treg) and 18F-FDG PET / CT in non-small cell lung carcinoma (NSCLC) Correlation of maximum standardized uptake value (SUVmax) and its impact on clinical prognosis. Methods: Clinical, imaging, pathology, tissue specimens and follow-up data of 122 patients with primary NSCLC admitted to Cancer Hospital of Tianjin Medical University from March 2008 to October 2014 were collected. Immunohistochemistry was used to detect Treg infiltration in lung cancer. The Kaplan-Meier method was used to analyze the survival of patients, and to analyze the correlation between Treg infiltration and SUVmax and the relationship with clinicopathological factors. Results: There was a positive correlation between Treg infiltration and SUVmax (r = 0.291, P = 0.001). Treg and SUVmax were divided into high and low groups by cutoff. Univariate analysis showed that Treg and SUVmax were the risk factors influencing the prognosis of patients. Clinical data analysis showed that the larger the tumor, the higher the tumor stage, the more severe Treg infiltration (P <0.05). Cox multivariate analysis showed that TNM staging of tumor (HR = 7.537, 95% CI: 1.191-2.855, P = 0.006) was an independent prognostic factor for survival in patients. CONCLUSIONS: Treg infiltration in NSCLC tissues is positively correlated with PET / CT SUVmax. PET / CT SUVmax can be used to predict Treg infiltration in the tumor microenvironment of NSCLC patients, which may be useful in judging the clinical prognosis and clinical medication of patients with NSCLC.