眼前段发育异常与相关基因

• 作 者: 高莉 姜发纲
• 机 构: 华中科技大学同济医学院附属协和医院眼科,华中科技大学同济医学院附属协和医院眼科,
• 出 处: 眼科新进展
• 发表日期: 2006年07期
• 关键词: 眼前段发育异常 青光眼 基因

眼前段发育异常不仅累及眼前段组织结构的形态异常,还可能改变房水引流系统的代谢和生理,患者常伴随眼压升高,继而发生青光眼。与眼球发育有关的基因突变是造成这些异常的重要原因,而这些基因产物的信号转导通路又相互联系,形成复杂的网络体系。我们就眼前段发育相关基因的研究进行综述。

Anterior segment dysplasia not only involves the morphological abnormalities of the anterior segment of the anterior segment, but also may change the metabolism and physiology of the aqueous drainage system. Patients often suffer from elevated intraocular pressure followed by glaucoma. Gene mutations associated with eye development are important causes of these abnormalities, and the signal transduction pathways of these gene products are linked to each other to form a complex network system. We review the development of the anterior segment of the relevant genes.