论文部分内容阅读
目的研究慈溪市人民医院呼吸内科2013—2015年细菌耐药率情况及抗菌药物用药频度(DDDs)间的关系,为临床合理用药提供选择依据。方法分析2013—2015年呼吸内科分离出的主要病原菌的耐药率及DDDs情况,采用SPSS.16.0统计软件分析其相关性。结果呼吸内科分离出的病原菌株数量最高的前5名为:嗜麦芽寡养单胞菌、鲍曼不动杆菌、阴沟肠杆菌、金黄色葡萄球菌,热带假丝酵母菌。DDDs值最高的前5名为左氧氟沙星、克拉霉素、头孢噻肟、哌拉西林他唑巴坦、制霉菌素。其中金黄色葡萄球菌对头孢噻肟的耐药率与其DDDs值存在相关性(r=0.99,P<0.05),其耐药率高于全院平均水平(P<0.05);阴沟肠杆菌对左氧氟沙星的耐药率与其DDDs值存在相关性(r=0.99,P<0.05),其耐药率与全院平均水平无显著性差异(P>0.05)。结论部分抗菌药物的DDDs值与细菌耐药率之间存在正相关,可作为临床选择抗生素治疗的依据之一。
Objective To study the relationship between the rate of bacterial resistance and the frequency of antidiastatic drugs (DDDs) in Respiratory Medicine of Cixi People’s Hospital from 2013 to 2015 so as to provide a basis for clinical rational drug use. Methods The drug resistance rates and DDDs of major pathogens isolated from respiratory medicine in 2013-2015 were analyzed. The correlations were analyzed by using SPSS 16.0 statistical software. Results The top five pathogens isolated from respiratory medicine were Stenotrophomonas maltophilia, Acinetobacter baumannii, Enterobacter cloacae, Staphylococcus aureus and Candida tropicalis. The top five DDDs were levofloxacin, clarithromycin, cefotaxime, piperacillin tazobactam, nystatin. Among them, the resistance rate of Staphylococcus aureus to cefotaxime was correlated with its DDDs (r = 0.99, P <0.05), and its resistance rate was higher than the average level of the whole hospital (P <0.05). Levofloxacin (R = 0.99, P <0.05). There was no significant difference in drug resistance rate with the average level of the hospital (P> 0.05). Conclusions There is a positive correlation between the DDDs value of some antibacterials and the rate of bacterial resistance, which can be used as a basis for clinical choice of antibiotics.