Synthesis,Characterization and Antibacterial Activity of 3-(2-(Heterocyclo-2-ylthio)-ethoxy)benzo[d]

• 作 者: 冯文 谢灵杰 宋煌旺 史载锋 王向辉 林强
• 机 构: Key Laboratory of Water Pollution Treatment and Resource Reuse of Hainan Province, College of Chemis
• 出 处: 结构化学
• 发表日期: 2017年06期
• 关键词: ethoxy benzo antibacterial triclinic belongs monoclinic Seven bonds membered for

Seven novel 3-(2-(heterocyclo-2-ylthio)ethoxy)benzo[d]isothiazoles(3a~3g) have been synthesized and characterized by ESI-MS and 1H and 13 C NMR spectra. The crystal structures of 3a and 3g have been determined. Compound 3a(C_(11)H_(11)N_5O_1S_2) belongs to the monoclinic system and 3g(C_(12)H_(11)N_3OS_3) to the triclinic system. The title compounds show excellent in vitro antibacterial activities, with the minimum inhibitory concentrations varying from 4 to 32 ug/m L.

The crystal structures of 3a and 3g have been synthesized and characterized by ESI-MS and 1H and 13C NMR spectra. The crystal structures of 3a and 3g (C_ (11) H_ (11) N_5O_1S_2) belongs to the monoclinic system and 3g (C_ (12) H_ (11) N_3OS_3) to the triclinic system. The title compounds show excellent in vitro antibacterial activities, with the minimum inhibitory concentration varying from 4 to 32 ug / m L.