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本文扼要介绍急性感染性腹泻治疗领域近年来研究的进展,主要包括特异性治疗和非特异性治疗两部分。前者为对抗肠毒素或阻断肠毒素作用的药物,针对病原体的抗菌或抗寄生虫药物应用,后者为补液治疗。WHO 推荐的口服补液盐(ORS)继续广泛应用于口服补液,但其配方、用法仍在不断改进和完善中。改变肠道动力的药物应掌握使用指征;吸附剂和改变肠道菌丛的药物即调整肠腔内菌态平衡的生物疗法以及作用机理尚未明瞭,但临床上的药物应用确实有良效,进一步研究有着广阔可喜的前景。
This article briefly describes the progress in the field of acute infectious diarrhea in recent years, including specific treatment and non-specific treatment in two parts. The former is to fight against enterotoxins or blocking the role of enterotoxin drugs, anti-bacterial or anti-parasitic agents for pathogen, the latter for rehydration therapy. Oral rehydration salts (ORS) recommended by the WHO continue to be widely used in oral rehydration, but its formulation and usage are still being improved and perfected. Change the intestinal motility of the drug should have indications for use; adsorbent and the change of intestinal flora drugs that regulate the balance of intestine bacteria biological therapy and the mechanism of action is not yet clear, but the clinical drug application does have good effect, Further research has broad and promising prospects.