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近十年来,对霍乱毒素的作用机制已作了深入研究。毒素是引起霍乱病的致病因子,产毒素霍乱孤菌在肠道细胞定居后繁殖产毒引起霍乱。感染的最终结果是由于细胞的环磷酸腺苷(cAMP)升高和肠道上皮细胞的正常离子流动障碍而引起大量腹泻和脱水。毒素本身为蛋白质大分子,现已知由三个亚单位(A_1、A_2、B的分子量分别为2900、5500,11500)构成。A_1亚单位具有酶活性,通过ADP-核糖基化影响腺苷环酶
In the past decade, the mechanism of action of cholera toxin has been studied in depth. Toxins are the causative agents that cause cholera disease. Cholera toxin is produced by cholera toxin-producing Cholera toxin after it colonizes intestinal cells. The end result of the infection is a large amount of diarrhea and dehydration due to increased cellular cAMP and normal ion flow disorders in the intestinal epithelium. The toxin itself is a protein macromolecule, and it is known that the toxin consists of three subunits (A 1, A 2 and B have molecular weights of 2900, 5500 and 11500, respectively). The A_1 subunit has enzymatic activity and affects adenosine cyclic enzyme through ADP-ribosylation