思密达治疗功能性肠胀气的临床研究

• 机 构: 西安医科大学第二附属医院消化内科
• 出 处: 华人消化杂志
• 发表日期: 1998年4期
• 关键词: ABDOMINAL DISTENSION/DRUG THERAPY SMECTA/THERAPEUTIC USE COLONIC DISEASES FUNCTI

目的评价思密达对功能性肠胀气的临床疗效及安全性,并探讨其治疗原理.方法采用随机分组、平行对照实验设计方法,观察功能性肠胀气患者60例,在应用思密达和安慰剂治疗后症状积分、呼氢值及肠内气体量的改变.结果与安慰剂比较,思密达能够明显降低功能性肠胀气患者临床症状积分、肠内胀气指数及3H呼氢值(0?9±0?2VS1?9±0?4,59±21VS184±82,16?1±2?4VS84?5±8?7,P＜0?01).思密达治疗功能性肠胀气的总有效率为90?0％,显著高于安慰剂的23?3％(χ2＝26?936,P＜0?01).思密达的主要副作用是便秘(6?7％),但大多数患者能够耐受.结论思密达能够抑制肠内细菌酵解,减少肠内气体,改善临床症状,且安全性好.“,”AIM To evaluate the efficacy and safety of Smecta in treatment of overful gas in intestinal tract of patients with alimentray dyskinesia. METHODS By using a randomized and controlled clinical trial, the changes of symptom score, the amount of expiratory hydrogen H 2 and intestinal gas in 60 patients were observed before and after the treatment. The patients were divided into Smecta group ( n =30) and placebo group ( n =30). RESULTS Compared with placebo, Smecta could significantly decrease the sympt...