实验性兔多器官功能障碍综合征的病理学研究

• 机 构: 国防科工委总医院
• 出 处: 华人消化杂志
• 发表日期: 1998年4期
• 关键词: MULTIPLE ORGAN FAILURE/PATHOLOGY MULTIPLE ORGAN FAILURE/DIAGNOSIS LUNG/PATHOLOGY

目的探讨MODS的病理组织形态特征,建立一种病理诊断指标.方法选用健康日本大耳白兔12只,随机分为实验与对照两组.实验组采用CLP法造成腹腔感染,制成MODS动物模型,对照组为假手术组.分别用光镜和电镜对主要器官的组织形态学变化进行观察.结果从光镜到电镜,实验组各器官组织均有相应不同程度的实质性改变.主要组织形态特征是:①构成器官的实质细胞变性坏死;②小血管、毛细血管扩张、瘀血,中性粒细胞聚集,微血栓形成;③间质水肿,炎细胞浸润.以肺、小肠表现最为显著.结论上述发现对于深入认识MODS的发病机制提供了病理学基础,可做为MODS时病理诊断的参考指标.“,”AIM To identify the histopathological characteristics of multiple organ dysfunction syndrome (MODS) and to establish a referring criterion for pathological diagnosis. METHODS Twelve healthy rabbits were divided randomly into two groups, experiment group ( n =8) and normal control group ( n =4). The animal model of MODS was established by using cecum ligature and perforation (CLP) in the experiment group. Histological changes of the main organs were individually observed under light microscope (LM) an...