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目的探讨左氧氟沙星不良反应(ADR)发生的规律和特点,为临床合理使用提供参考。方法对148例使用左氧氟沙星患者的不良反应报告进行汇总和统计分析。结果左氧氟沙星的不良反应主要有变态反应、神经系统损害、关节软组织损害、循环系统损害以及低血糖等,并且不良反应的发生与患者年龄、用药方法、给药时间有一定的关系。结论为减少左氧氟沙星不良反应的发生,应合理使用,严格掌握左氧氟沙星的临床适应症,尽量使用口服途径给药,必须采用静脉给药时,静滴过程中要严格控制滴速和滴注浓度,并密切观察。
Objective To investigate the regularity and characteristics of levofloxacin adverse reactions (ADRs) and provide references for clinical rational use. Methods Adverse reactions of 148 patients with levofloxacin were summarized and statistically analyzed. Results The main adverse reactions of levofloxacin were allergic reaction, nervous system damage, joint and soft tissue damage, circulatory system damage and hypoglycemia. The incidence of adverse reactions was related to patient's age, medication method and administration time. Conclusion In order to reduce the incidence of levofloxacin adverse reactions, it should be used rationally and the clinical indications of levofloxacin should be strictly grasped. When oral administration is the best, intravenous drip must be used to control drip rate and drip concentration during intravenous infusion Close observation.