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目的：探讨以中药为主的中西医结合疗法治疗免疫异常增高型反复自然流产的临床价值及其作用机理。方法：免疫异常增高型反复自然流产透明带抗体阳性者采用知柏地黄丸治疗；磷脂抗体及ＡＢＯ血型机体阳性者采用清热利湿、养血活血中药复方治疗，磷脂抗体阳性者加用阿司匹林口服。结果：经治疗后，再次妊娠成功率为９２．３％。在治疗过程中，透明带抗体、磷脂抗体及ＡＢＯ血型抗体水平呈明显下降。妊娠后透明带抗体水平无明显再次升高现象；而磷脂抗体及ＡＢＯ血型抗体水平于妊娠后再度升高，但经继续治疗后又呈明显下降。结论：中药复方主要通过降低异常增高的自身及同种抗体水平，可有效治疗免疫异常增高型反复自然流产。
Objective: To explore the clinical value and mechanism of treatment of recurrent spontaneous abortion with abnormal immune abnormity combined traditional Chinese and western medicine based on traditional Chinese medicine. Methods: Zhibai Dihuang Wan was used in the patients with abnormal immune abnormity spontaneous abortion zona pellucida. Phospholipid antibodies and ABO blood group were treated with Qingre dampness, nourishing blood and promoting blood circulation. The patients with positive phospholipid antibodies plus oral aspirin. Results: After treatment, the success rate of re-pregnancy was 92.3%. In the course of treatment, zona pellucida, phospholipid antibodies and ABO blood group antibody levels decreased significantly. After the pregnancy, there was no significant increase in the level of antibody in the zona pellucida; however, the levels of phospholipid antibodies and ABO blood group antibody increased again after pregnancy, but decreased significantly after continued treatment. Conclusion: The traditional Chinese medicine compound can effectively treat recurrent spontaneous abortion with abnormally elevated immune system mainly by reducing the level of abnormally elevated self and alloantibodies.