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目的:通过观察莪术油对乳腺癌癌前病变造模大鼠乳腺组织病理形态的影响,探讨莪术油对乳腺癌癌前病变的治疗作用。方法:将256只SD大鼠随机分为空白对照组、疾病模型组、三苯氧胺组、康莱特组及莪术油大、中、小剂量组。采用DMBA诱导乳腺癌癌前病变造模,第2天开始进行干预治疗,分别于第8周末、第10周末、第12周末、第14周末进行组织病理学观察、分析。结果:疾病模型组与空白对照组比较,大鼠死亡率、癌前病变发生率、乳腺癌发生率增高(P<0.05)。莪术油中、小剂量组大鼠死亡率、癌前病变发生率、乳腺癌发生率降低,与病模组及康莱特组比较差异显著(P<0.05),与三苯氧胺组比较无显著差异(P>0.05)。结论:莪术油可降低乳腺癌癌前病变造模大鼠的癌变发生率及死亡率,可在癌前病变阶段预防、逆转、阻断乳腺癌的发生发展。
Objective: To observe the effect of zedoary turmeric oil on the histopathology of mammary gland in rats with precancerous lesions of breast, and to explore the therapeutic effect of zedoary turmeric oil on precancerous lesions of breast cancer. Methods: 256 SD rats were randomly divided into blank control group, disease model group, tamoxifen group, Kanglaite group and Zedoary oil large, medium and small dose groups. DMBA was used to induce breast cancer precancerous lesions and the intervention was started on the second day. Histopathological examination and analysis were performed on the 8th, 10th, 12th and 14th week respectively. Results: Compared with the blank control group, the mortality rate, the incidence of precancerous lesions and the incidence of breast cancer in the model group were significantly increased (P <0.05). The results showed that there was significant difference between the model group and Kanglaite group (P <0.05), but no significant difference with the tamoxifen group (P <0.05) > 0.05). Conclusion: Ezhu oil can reduce the incidence of cancer and mortality in rats with precancerous lesions of breast cancer, prevent, reverse and block the occurrence and development of breast cancer in precancerous lesions.