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目的观察丹皮总甙（ＴＧＭ）的抗肝炎作用。方法采用ＣＣｌ４和ＤＧａｌＮ诱导小鼠化学性肝损伤模型。结果ＴＧＭ可降低ＣＣｌ４和ＤＧａｌＮ所致血清ＡＬＴ、ＡＳＴ的升高，减轻ＣＣｌ４和ＤＧａｌＮ所致肝脏变性和坏死程度，预防给药效果优于治疗给药，其中以５０ｍｇ·ｋｇ－１剂量组给药７天效果最佳。结论ＴＧＭ对化学性肝损伤有一定程度的保护作用。
Objective To observe the anti-hepatitis effect of daphnidone (TGM). Methods CCl4 and DGalN induced chemical liver injury model in mice. Results TGM can reduce the CCl4 and D GalN serum ALT, AST increased, reduce CCl4 and D GalN liver degeneration and necrosis caused by the prevention of drug delivery is better than the treatment, in which 50mg Kg-1 dose group administered 7 days best. Conclusion TGM has a certain degree of protective effect on chemical liver injury.