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探讨环磷酰胺联合疗法治疗儿童原发性肾病综合征（肾病）的价值。方法将93例肾病患儿随机分为CTX联合疗法组（CTX组）或单用激素疗法组（对照组），其中21例进行了重复肾活检。对肾病患儿治疗前后的临床疗效、肾脏组织病理变化及环磷酰胺毒性反应进行长期观察及对照分析。结果1．CTX联合治疗组的基本治疗愈率明显高于单用激素组；2．CTX联合疗法能明显减轻肾组织病理改变；3．CTX的疗效与病理类型有关；4．CTX联合组未见严重副作用。结论联合应用CTX治疗能提高肾病基本治愈率。
To investigate the value of cyclophosphamide combined therapy in treating children with primary nephrotic syndrome (nephropathy). Methods Ninety-three children with nephrotic syndrome were randomly divided into CTX combined therapy group (CTX group) and hormone therapy alone group (control group). 21 of them were subjected to repeated renal biopsy. The clinical efficacy of children with nephropathy before and after treatment, renal histopathological changes and cyclophosphamide toxicity response to long-term observation and control analysis. Results 1. CTX combination therapy group was significantly higher than the cure rate of single hormone group; 2. CTX combination therapy can significantly reduce renal pathological changes; 3. CTX efficacy and pathological type; 4. CTX combined group no serious side effects. Conclusion The combination of CTX treatment can improve the basic cure rate of nephropathy.