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为研究血管发生在早期胃癌进展中的作用及其与病理特征和预后的关系，我们采用抗第八因子相关性抗原的抗体，以ABC法检测了41例早期胃癌的微血管数。结果表明，早期胃癌的微血管分布不均匀，呈异质性，平均数目为22．5根。有淋巴管浸润或侵及粘膜下层时，其微血管数显著增多（P＜0．01）。呈浸润性生长或有淋巴结转移时，微血管数亦有增多倾向（P＞0．05）。微血管数多于23根的患者，术后生存期和5年生存率明显降低（P＜0．05）。提示血管发生可能影响早期胃癌的进展和预后。
In order to study the role of angiogenesis in the progression of early gastric cancer and its relationship with pathological features and prognosis, we used anti-factor VIII related antigen antibody to detect the number of microvessels in 41 cases of early gastric cancer by ABC method. The results showed that the microvessels in early gastric cancer were unevenly distributed and heterogeneous with an average number of 22.5. When lymphatic vessels infiltrated or invaded the submucosa, the number of microvessels increased significantly (P<0.01). When infiltrative growth or lymph node metastasis, the number of microvessels also increased (P>0.05). In patients with more than 23 microvessels, the postoperative survival time and 5-year survival rate were significantly lower (P<0.05). It suggests that angiogenesis may affect the progress and prognosis of early gastric cancer.