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目的:观察高血压患者应用天麻钩藤饮联合赖诺普利氢氯噻嗪片治疗临床疗效及其安全性。方法:本组81例高血压患者根据随机数字表法随机分为治疗组(n=43)和对照组(n=38)。对照组给予赖诺普利氢氯噻嗪片治疗,治疗组在对照组基础上加用天麻钩藤饮治疗。两组患者均连续治疗2个疗程,共4周。疗程结束后对比分析两组患者临床治疗总有效率,治疗前后症状积分变化、血压变化、心率变化及治疗过程中不良反应发生情况。结果:治疗组总有效率(95.35%)显著高于对照组(73.68%)(P<0.05);治疗组治疗后头痛、眩晕、失眠多梦、口苦面红症状积分显著低于治疗前及对照组(P<0.05);治疗后治疗组收缩压和舒张压显著低于治疗前及对照组;治疗前后两组患者心率比较均不具有统计学差异(P>0.05);两组治疗过程中均未出现明显不良反应。结论:高血压患者应用天麻钩藤饮联合赖诺普利氢氯噻嗪片治疗临床疗效显著,安全可靠,具有重要临床研究价值。
Objective: To observe the clinical efficacy and safety of Tianma Gouteng Decoction combined with lisinopril hydrochlorothiazide in hypertensive patients. Methods: 81 patients with hypertension were randomly divided into treatment group (n = 43) and control group (n = 38) according to random number table method. The control group was treated with lisinopril hydrochlorothiazide tablets, the treatment group was treated with Tianma Gouteng Decoction on the basis of the control group. Two groups of patients were treated for 2 courses, a total of 4 weeks. After the end of treatment, the total effective rate of clinical treatment, the change of symptom scores, the changes of blood pressure, heart rate and adverse reactions during the treatment were compared between the two groups. Results: The total effective rate (95.35%) in the treatment group was significantly higher than that in the control group (73.68%) (P <0.05). The scores of headache, dizziness, insomnia and dreaminess in the treatment group were significantly lower than those in the control group (P <0.05). After treatment, systolic blood pressure and diastolic blood pressure in treatment group were significantly lower than those before treatment and in control group. There was no significant difference in heart rate between the two groups before and after treatment (P> 0.05) No obvious adverse reactions. Conclusion: The clinical efficacy of Tianma Gouteng Decoction combined with lisinopril hydrochlorothiazide tablets is significant, safe and reliable, and has important clinical research value.