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目的 :应用小分子肝素 (LMWH)、三氧化二砷 (As2 O3 )治疗急性早幼粒细胞白血病 (APL)合并弥散性血管内凝血 (DIC)疗效的观察 ,方法 :APL诊断确定即开始皮下注射LMWH和静滴AS2 O3 ,D -二聚体阴性时则停用LMWH。结果 :初治和复发病例中亚急性和慢性DIC疗效较好 ,初治病例中急性DIC疗效差。总治愈率为 90 % ,副反应轻。结论 :LMWH利As2 O3 联合应用治疗APL合并DIC的治愈率高 ,LMWH和As2 O3 是目前治疗APL合并DIC较理想的药物。
Objective: To observe the curative effect of low molecular weight heparin (LMWH) and arsenic trioxide (As2O3) on acute promyelocytic leukemia (APL) and diffuse intravascular coagulation (DIC). Methods: Dropped AS2 O3, D-dimer was deactivated when LMWH. Results: The efficacy of subacute and chronic DIC in newly diagnosed and relapsed cases was better, and the effect of acute DIC in initial treated cases was poor. The total cure rate was 90%, mild side effects. Conclusion: The combination of LMWH and As2 O3 in the treatment of APL complicated with DIC has a high cure rate. LMWH and As2O3 are the ideal drugs for the treatment of APL combined with DIC.