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目的探讨救治急性重度有机磷农药中毒时阿托品效应低下的原因。方法根据患者入院时的临床表现、实验室检查选定急性重度有机磷农药中毒80例,分析应用阿托品效应低下的影响因素及转归。结果未达到阿托品化的18例均死亡,病死率100%;达到阿托品化的62例患者中死亡8例,病死率12.9%。结论急性重度有机磷农药中毒救治中阿托品效应低下者预后极差,除受毒物品种、中毒程度、中毒途径、就诊时间影响外,还受残毒吸收、严重的并发症、医源性等综合因素影响。
Objective To investigate the reasons for the low effect of atropine in the treatment of acute severe organophosphorus pesticide poisoning. Methods According to the clinical manifestations of patients admitted to the hospital, 80 cases of acute severe organophosphorus pesticide poisoning were selected by laboratory tests. The influencing factors and prognosis of low effect of atropine were analyzed. Results None of the 18 cases of atropisation were dead, the case fatality rate was 100%; 62 cases of atropine to death in 8 patients, the mortality rate of 12.9%. Conclusion The prognosis of patients with acute severe organophosphorus pesticide poisoning in the treatment of low atropine effect is very poor. Apart from the effects of poisoning variety, poisoning degree, poisoning path, and treatment time, it is also affected by the combined effects of residual drug absorption, serious complications and iatrogenicity .