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环磷酸胺是临床上常用的抗肿瘤药物和免疫抑制剂，是化学致畸物研究的代表药，体外致畸试验方法是研究致畸作用及机理的有效方法之一；本文以环磷酰胺为例，从前致畸原体外活化、体外给药方法及试验方法几个方面较系统也介绍了该药体外致畸的研究情况，这对其它化学物质的致畸研究可能有一定参考价值。
Cyclophosphamide is commonly used in clinical anticancer drugs and immunosuppressive agents, is the representative of chemical teratology research, in vitro teratogenicity test method is one of the effective methods of teratogenicity and mechanism of action; cyclophosphamide For example, the former teratogen activation in vitro, in vitro administration methods and test methods in several aspects of the system also introduced the drug in vitro teratogenic research, which teratogenic study of other chemicals may have some reference value.