论文部分内容阅读
目的探讨垂体腺瘤质地与相关临床和病理特征的关系。方法由2名影像科医生独立评估30例垂体腺瘤患者的MRI常规序列资料。神经外科医生在术后将病例分为A组(瘤体质地软,22例)和B组(瘤体质地坚韧,8例),采用天狼星红染色检测肿瘤组织中的胶原蛋白。结果垂体腺瘤质地与患者的临床特征如性别、肿瘤大小和生长方式无明显相关。A、B两组瘤体与T1WI白质的信号比相仿(0.8791±0.1078vs.0.8872±0.1023)(P>0.05);但A组瘤体与T2WI白质的信号比大于B组(1.7573±0.2622vs.1.5220±0.1839)(P<0.05)。A组肿瘤组织胶原含量(IPP图像分析系统计算面积百分比)少于B组[(13.210±3.499)%vs.(35.450±8.125)%](P<0.05)。结论T2WI上的垂体腺瘤瘤体白质的信号比与垂体腺瘤质地相关;垂体腺瘤的质地可能与胶原沉积相关。
Objective To explore the relationship between pituitary adenoma texture and related clinical and pathological features. Methods Two MR imaging radiologists independently evaluated MRI sequences of 30 patients with pituitary adenoma. The neurosurgeons divided the patients into A group (22 soft tissues) and B group (8 solid tumors) after operation. The collagen in tumor tissues was detected by Sirius red staining. Results There was no significant correlation between the texture of pituitary adenomas and the clinical features such as gender, tumor size and growth pattern. The signals of A and B groups were similar to that of T1WI white matter (0.8791 ± 0.1078 vs.0.8872 ± 0.1023) (P> 0.05), but the signal ratio of A group and T2WI white matter was greater than that of B group (1.7573 ± 0.2622 vs. 1.5220 ± 0.1839) (P <0.05). Collagen content of tumor tissue in group A (calculated by IPP image analysis system) was less than that in group B [(13.210 ± 3.499)% vs (35.450 ± 8.125)%] (P <0.05). Conclusion The signal ratio of white matter in pituitary adenomas on T2WI is related to the texture of pituitary adenomas. The texture of pituitary adenomas may be related to collagen deposition.