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目的总结艾滋病(AIDS)合并卡波西肉瘤病人的临床特征及治疗转归。方法选取北京佑安医院2004年1月至2015年1月收治的7例艾滋病合并卡波西肉瘤病人的病例资料,对其临床特征、治疗以及疾病转归进行回顾性调查分析。结果 7例艾滋病合并卡波西肉瘤病人均为男男性行为者(MSM),年龄中位数为34岁(22~51岁),6例汉族,1例回族。皮肤黏膜均受累,口腔黏膜受累5例,局部淋巴结肿大4例,肺部受累3例,肝脏受累1例,球结膜受累1例。病人CD+4T淋巴细胞计数均<200个/mm3,其中6例(85.7%)CD+4T淋巴细胞<100个/mm3。5例病人治疗后病情均好转,其中4例病人应用抗反转录病毒治疗(ART)联合全身化疗,1例病人单用ART,2例病人放弃治疗后死亡。结论 MSM中艾滋病晚期合并卡波西肉瘤的病人,如不进行治疗预后极差,部分病人单独应用ART病灶即可消退,病变广泛者联合全身化疗疗效较好。
Objective To summarize the clinical features and treatment outcome of AIDS patients with Kaposi’s sarcoma. Methods The data of 7 cases of AIDS patients with Kaposi’s sarcoma who were treated in Beijing You’an Hospital from January 2004 to January 2015 were retrospectively analyzed. The clinical features, treatment and disease outcome were retrospectively analyzed. Results All 7 AIDS patients with Kaposi’s sarcoma were MSM. The median age was 34 (22-51), 6 Han and 1 Hui. 5 cases of oral mucosa involvement, 4 cases of local lymph nodes, 3 cases of lung involvement, 1 case of liver involvement, and 1 case of conjunctival involvement. The CD + 4T lymphocyte counts of all patients were less than 200 / mm3. Among 6 patients (85.7%), CD + 4T lymphocytes <100 cells / mm3.5 patients improved after treatment, of which 4 patients were anti-retroviral ART combined with systemic chemotherapy, 1 patient with ART alone and 2 patients withdrew after treatment and died. Conclusion In MSM, patients with advanced AIDS complicated with Kaposi’s sarcoma may have very poor prognosis if they are not treated. Some patients may subside with ART alone, and those with extensive disease and combined with systemic chemotherapy have better outcomes.