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TREM-1是一种免疫球蛋白超家族活化受体,目前研究已发现,TREM-1可参与炎症反应,在脓毒症、肺炎、急性病毒性心肌炎等疾病的发病中发挥重要作用。而在类风湿性关节炎、红斑狼疮、炎症性肠病等自身免疫性疾病中对TREM-1的研究较少。本文对TREM-1的结构特点、信号传导通路及与疾病关联进行分析与归纳,探索TREM-1与炎症性疾病尤其是自身免疫性疾病的关联性,为临床对疾病的诊断与治疗提供参考依据。
TREM-1 is an immunoglobulin superfamily activated receptor. Up to now, TREM-1 has been found to play an important role in the inflammatory response and plays an important role in the pathogenesis of sepsis, pneumonia and acute viral myocarditis. However, there are few studies on TREM-1 in autoimmune diseases such as rheumatoid arthritis, lupus erythematosus and inflammatory bowel disease. In this paper, the structural features of TREM-1, signal transduction pathways and the relationship between the disease were analyzed and summarized to explore the correlation between TREM-1 and inflammatory diseases, especially autoimmune diseases, to provide a reference for the clinical diagnosis and treatment of the disease .