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近年有学者认为急性心肌梗死(AMI)病人发生的免疫学障碍是决定该病病程经过和促进病情恶化的1个因素。许多研究确定,在AMI时发生的心肌损伤能促使形成心肌自身抗原并产生相应的抗心肌抗体。本文报告作者关于AMI病人的免疫学特点进行研究的结果。共选择26例大面积AMI病人(平均年龄54.26±1.1岁)为研究对象(心梗组),入院后采用传统的心肌梗死疗法进行治疗,设26例年龄相同的健康人为对照组。对心梗组病人和对照组受检者均在入院和出院时测定以下免疫学指标:T细胞[包括辅助T细胞(T_H)和抑制T细胞(Ts)计数],B细胞计数,免疫球蛋白(IgG、IgA、IgM)含量,循环免疫复合物水平,嗜中性粒细胞吞噬活性,抗心磷脂抗体和抗磷脂抗体浓度并对比两组的测定结果,进行统学处理。
In recent years, some scholars believe that the occurrence of immunological disorders in patients with acute myocardial infarction (AMI) is a factor in determining the course of the disease and promote the deterioration of the disease. Many studies have determined that myocardial damage that occurs during AMI can promote the formation of cardiac autoantigen and produce the corresponding anti-myocardium antibody. This article reports the authors’ findings regarding the immunological characteristics of patients with AMI. A total of 26 AMI patients (mean age 54.26 ± 1.1 years) were selected as the study group (MI group). After admission, they were treated by traditional myocardial infarction therapy. Twenty-six healthy people of the same age as the control group. The following immunological indicators were measured at admission and at discharge in both MI patients and control subjects: T cells [including T helper (T_H) and T cell (T) count inhibition], B cell count, immunoglobulin (IgG, IgA, IgM) levels, circulating immune complex levels, phagocytic activity of neutrophils, anticardiolipin and antiphospholipid antibody concentrations were compared with those of the two groups.