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目的分析和研究不同剂量辛伐他汀治疗老年高脂血症效果对比。方法高脂血症老年患者200例,将其按数字随机表法分为观察组100例与对照组100例。对照组患者给予辛伐他汀10mg口服治疗;观察组患者给予辛伐他汀20 mg口服治疗,将两组患者治疗3个月后的疗效及不良反应发生率进行对比。结果观察组患者治疗后的血脂水平检测值明显优于对照组,差异具有统计学意义(P<0.05)。两组患者不良反应发生率差异无统计学意义(P>0.05)。结论将辛伐他汀20 mg/d剂量应用于老年高脂血症患者治疗中,能够有效降低患者血脂水平值,其与10 mg/d剂量相比较,疗效更优,并且不增加毒副作用,安全可靠,对有效控制高脂血症病情发展及降低并发症发生有积极的作用。
Objective To analyze and study the effects of different doses of simvastatin on senile hyperlipidemia. Methods 200 cases of elderly patients with hyperlipidemia were divided into observation group (100 cases) and control group (100 cases) by digital random table method. Patients in the control group were treated with 10 mg of simvastatin orally; patients in the observation group were treated with 20 mg of simvastatin orally, and the efficacy and adverse reactions of the two groups were compared after 3 months of treatment. Results The observation group’s blood lipid level after treatment was significantly better than the control group, the difference was statistically significant (P <0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P> 0.05). Conclusion Simvastatin 20 mg / d can be used to treat elderly patients with hyperlipidemia, which can reduce the level of blood lipid in patients with hyperlipidemia. Compared with the 10 mg / d dose, simvastatin has better efficacy and no side effects and safety Reliable, and effective control of the development of hyperlipidemia and reduce the incidence of complications have a positive effect.