论文部分内容阅读
目的 恶性肿瘤化疗的一个最大问题是肿瘤对化疗药物的耐药性。MTT肿瘤药敏检测是一种定量比色体外药敏测定方法。本研究的目的是初步评价 MTT药敏检测结果对指导口腔肿瘤个体化化疗的临床意义。方法 应用 30例口腔颌面外科手术或活检的恶性肿瘤标本 ,进行常规 MTT药敏检测 ,同时将检测结果与临床资料进行对比性分析。检测药物共有 6种 :DDP、5 - Fu、VDS、MTX、E- ADM、PYM。结果 (1)病变部位以舌部为主 ,占30 % ,药物敏感性与肿瘤部位有关 ;(2 )检测 30例口腔颌面部恶性肿瘤组织的药敏性 ,所得结果与临床资料进行分析。8例采用传统经验用药方案进行化 ,其疗效与 MTT法检测的药敏结果一致 ;(3)大部分肿瘤对 DDP、5 - Fu有中度以上敏感性 ,但也有少部分存着抗 DDP、5 - Fu现象 ,这也是临床上采用传统经验用药方案 ,有些肿瘤化疗效果不理想的原因之一。结论 通过肿瘤药敏检测 ,找出对恶性肿瘤有效的化疗药物组成联合用药方案 ,可以做到化疗方案的个体化 ,进而提高疗效
Purpose One of the biggest problems with malignant tumor chemotherapy is its resistance to chemotherapeutic drugs. MTT tumor drug sensitivity test is a quantitative assay of drug sensitivity. The purpose of this study is to evaluate the clinical significance of MTT susceptibility testing in individualized chemotherapy for oral cancer. Methods 30 cases of oral and maxillofacial surgery or biopsy of malignant tumor specimens were used for routine MTT drug sensitivity test, and the test results and clinical data for comparative analysis. There are 6 kinds of test drugs: DDP, 5 - Fu, VDS, MTX, E - ADM, PYM. Results (1) The lesion was mainly tongue, accounting for 30%. The drug sensitivity was related to the tumor site. (2) The sensitivity of 30 cases of oral and maxillofacial malignant tumor was detected. The results and clinical data were analyzed. 8 cases were treated with traditional experience regimen, and the curative effect was consistent with that of MTT assay. (3) Most of the tumors were moderately sensitive to DDP and 5 - Fu, but a few of them also had anti - DDP, 5 - Fu phenomenon, which is also the clinical experience of the traditional experience with the drug program, and some tumor chemotherapy results are not ideal one of the reasons. Conclusion Through the drug susceptibility testing, to find out the effective combination of chemotherapy drugs for malignant tumor drug combination program can be personalized chemotherapy program, and thus improve the efficacy