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30%～45%胰岛素依赖性糖尿病(IDDM)患者并发症糖尿病肾病,后者是增加病死率的主要原因。肾病早期迹象是尿白蛋白排泄率(AER)持久增加,但不能用常规方法检出。微量白蛋白尿持续,预示有糖尿病肾病。本文评价血管紧张素抑制剂(ACE)Cap-topril(巯甲丙脯酸)对血压正常伴微量白蛋白尿IDDM患儿的疗效。方法糖尿病门诊210例12岁～18岁的IDDM患儿,3个月内先以1小时集尿筛查微量白蛋白尿。阳性者(AER15～200μg/分)则收集2次24小时尿液检查,以确诊AER升高。11例AER阳性,按下列标准再次筛选:(1)第3次24小时尿液微量白蛋白尿阳性;(2)IDDM病程≥2年;(3)该血压≤该年
Complications of diabetic nephropathy in 30% to 45% of patients with insulin-dependent diabetes mellitus (IDDM), the latter being the leading cause of increased mortality. Early signs of nephropathy are long-lasting increases in urinary albumin excretion (AER) but can not be detected by routine methods. Microalbuminuria continued, indicating diabetic nephropathy. This article evaluates the efficacy of angiotensin-converting enzyme (ACE) Cap-topril in children with normotensive and microalbuminuric IDDM. Methods A total of 210 IDDM children aged 12-18 years old with diabetes clinic were enrolled in this study. Micro urine albuminuria was detected by urine collection for 1 hour in 3 months. Positive (AER15 ~ 200μg / min) is collected twice a 24-hour urine test to confirm elevated AER. Eleven patients with AER positive were screened again according to the following criteria: (1) urine microalbuminuria for the third 24-hour urine test; (2) IDDM course for more than 2 years; (3) blood pressure ≤ the year