论文部分内容阅读
目的探讨中药注射剂静脉滴注时的不良反应特征及预防措施。方法选择天津市东丽医院2013年1月-2015年12月期间因中药注射剂静脉滴注引发的70例不良反应病例作为研究对象,收集不良反应病例的临床资料,分析不良反应的特点和涉及的中药注射剂类别。根据不良反应统计结果探讨合理防范不良反应的对策。结果不良反应在静脉滴注10~60 min内发生率最高;≥3种药物联用致不良反应发生率最高;皮肤及其附件不良反应发生率最高,消化系统次之;在不良反应涉及中药注射液中,热毒宁、清开灵注射液等清热剂、祛湿剂构成比最高,刺五加注射液次之,差异均有统计学意义(P<0.05)。结论中药注射剂成分复杂,静脉滴注时易发生不良反应,应注意过敏史,尽量避免多种药物联合使用,合理配伍药物,从而减少不良反应的发生。
Objective To investigate the adverse reaction characteristics of traditional Chinese medicine injection and its preventive measures. Methods Toray Hospital of Tianjin from January 2013 to December 2015 caused by intravenous infusion of Chinese medicine injection of 70 cases of adverse reactions as the research object, collect the clinical data of adverse reactions, analyze the characteristics of adverse reactions and involved Chinese medicine injection category. Based on the statistical results of adverse reactions, the countermeasures of reasonable prevention of adverse reactions were explored. Results Adverse reactions occurred most frequently within 10-60 minutes after intravenous drip. The incidence of adverse reactions was the highest among ≥3 kinds of drugs, the incidence of adverse reactions of skin and its accessories was the highest, followed by the digestive system, Liquid, heat poisoning, Qingkailing injection and other heat-clearing agents, Qushi composition ratio highest, acanthopanax injection followed, the difference was statistically significant (P <0.05). Conclusion Traditional Chinese medicine injection composition is complex, prone to adverse reactions when intravenous drip, should pay attention to the history of allergies, try to avoid the combination of multiple drugs, rational compatibility of drugs, thereby reducing the incidence of adverse reactions.