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一、简史1817年,瑞典化学家 Arfvedson 在透锂长石中发现了锂元素。1861年 Garrod 发表论著,提到试用锂治疗痛风。这个大概是锂应用于医学领域的最早的文献。然而用锂治疗痛风是不成功的。其后在近80年时间里,锂在医学领域中的应用状况十分萧条。1949年,Cade 在研究尿素对豚鼠的毒性作用时,发现锂可对抗尿素引起的痉挛,于是把锂试用于10名躁狂症患者的治疗,得到了戏剧性的成功。不久,锂便作为抗躁狂症的有效药
First, a brief history In 1817, the Swedish chemist Arfvedson found lithium in lithium feldspar. Garrod published a treatise in 1861, referring to the trial of lithium for the treatment of gout. This is probably the earliest literature on lithium used in medicine. However, the treatment of gout with lithium is unsuccessful. In the nearly 80 years later, the application status of lithium in the medical field was very sluggish. In 1949, when studying the toxic effects of urea on guinea pigs, Cade found that lithium was able to counteract the spasms caused by urea and thus had a dramatic success with the trial of lithium in 10 manic patients. Soon, lithium is an effective anti-mania medicine