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目的制作大鼠溃疡性结肠炎(UC)模型,研究NO的意义,观察中药复方胃肠康的作用.方法SD大鼠随机分健康对照组(13只)、模型组(28只)、模型+胃肠康组(17只)和模型+强的松组(16只).后3组61只大鼠以二硝基氯苯法制作UC模型.动物颈背部剃毛后,以20G/(L?D)的2,4?二硝基氯苯丙酮液滴背1次,每次每鼠5滴.连用14D致敏.其后每日向肛内6CM处的结肠肠腔灌10G/L二硝基氯苯乙醇(0?5L/L)液1次,每次每鼠0?35ML,连续4D.复方胃肠康为柴胡、艾叶等4味中药的1?1KG/L水煎剂,每日每鼠灌胃1ML.醋酸强的松为对照药.两种药物均应用临床等效量,连用6D.实验完成后处死动物,肉眼观察大肠粘膜,并取8CM肠段,置2ML蒸馏水浸泡,浸泡液参照GREEN方法测定NO代谢物(NOP).而后肠段固定,HE染色,作光镜病理检查.结果大鼠14只在造模后因病重或其他原因死亡.8只造模大鼠在造模完成后作病理抽检,发现其结肠都有炎症和典型的溃疡,NOP(μMOL/L)为2?64±0?86,显著高于健康大鼠的1?71±1?14.应用胃肠康及强的松后,两造模+治疗组动物结肠的炎症减轻,溃疡数目及面积均较模型对“,”AIM To establish a rat ulcerative colitis (UC) model with abnormal NO and observe the effect of Chinese medicine compound Weichangkang. METHODS RESULTS Fourteen rats died. All 8 model rats checked pathologically had UC, and the level of NOP (μmol/L) in the model group (2 64±0 86) was significantly higher than that of normal control group (1 71±1 14). Both UC groups of model+treatment with Weichangkang or prednisone had better improvement than the control group. CONCLUSION Abnormal NO was important...