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目的研究梗阻性黄疸免疫功能及其与内毒素血症的相关性.方法检测28例梗阻性黄疸患者及20例健康对照者血清内毒素,T淋巴细胞亚群及血清SIL2R的水平.结果梗阻性黄疸患者血清内毒素和SIL2R水平较对照组明显升高(47?0NG/L±11?3NG/L和725KU/L±201KU/LVS28?4NG/L±10?3NG/L和324KU/L±116KU/L,P＜0?01),T淋巴细胞亚群CD3,CD4,CD4/CD8明显降低(50?4％±3?3％和29?9％±3?8％VS63?8％±4?4％和38?3％±2?8％,P＜0?01;1?22±0?32VS1?43±0?37,P＜0?05),同时亦发现梗阻性黄疸内毒素血症组较非内毒素血症组CD3,CD4水平明显减低,SIL2R水平明显升高(47?4％±5?1％和27?6％±5?2％和867KU/L±231KU/LVS52?3％±5?2％和31?2％±4?3％和674KU/L±189KU/L,P＜0?05).相关分析显示血清内毒素水平与血清SIL2R水平呈显著正相关(R＝0?8517,P＜0?01).结论梗阻性黄疸时内毒素血症与免疫功能状态密切相关.“,”AIM To investigate the relationship between endotoxemia and cellular immunity in patients with obstructive jaundice. METHODS Serum endotoxin levels, Tlymphocyte subsets, and serum soluble interleukin 2 receptor (SIL 2R) were studied in 28 patients with obstructive jaundice and 20 controls. RESULTS The serum endotoxin levels and SIL 2R were significantly higher ( 47 0ng/L ± 11 3ng/L and 725kU/L ± 201kU/L vs 28 4ng/L ± 10 3ng/L and 324kU/L ± 116kU/L , P