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目的探索螺内酯对门脉高压实验犬和肝硬变患者门脉血流动力学的作用.方法用直接门脉插管测压和99MTC?MIBI心肝放射性摄取比值(H/L)测定慢性胆总管结扎肝硬变犬(N＝16)门静脉压力和门体分流,口服螺内酯2?0MG/(KG?D).肝硬变患者14例测定H/L,门静脉内径和流速后口服螺内酯80MG/D,4WK为1疗程.结果完成试验的犬13只治疗前后门脉压力(KPA)从2?59±0?51下降为2?42±0?47(P＜0?05),H/L从0?33±0?06降至0?30±0?08(P＜0?05).14例肝硬变患者治疗前后H/L值从1?20±0?26降为1?02±0?34(P＜0?05),门脉内径(MM)从13?9±2?3缩小为12?3±2?0(P＜0?05).门静脉流速明显增加.结论螺内酯口服可降低门脉压力和门体分流.“,”AIM To study the effects of spironolactone on portal hemodynamics of cirrhotic dogs and patients. METHODS Portal venous pressure and 99mTc MIBI heart liver radioisotopic take up ratio (H/L) were determined in 16 cirrhotic dogs induced by chronic common bile duct ligation. Heart liver radioisotopic take up ratio, diameter of portal vein and portal venous velocity were determined by pulsed Doppler ultrasonography in 14 cirrhotic patients. Afterwards, spironolactone was given orally...