论文部分内容阅读
夹闭大鼠肠系膜上动脉1h后松夹,于松夹前分别给予超氧化物歧化酶(superoxide dismutasv, SOD)、过氧化氢酶(catalase, CAT)、别嘌呤醇(allopurinol, ALLO)、SOD+CAT、SOD+ALLO和SOD+CAT+ALLO。结果表明,除单用CAT外,其他单用或伍用自由基清除酶(剂)均有抗脂质过氧化损伤效应,表现为应用自由基清除酶(剂)能明显抑制肠、心、肝、肺组织中丙二醛(malodialdehyde, MDA)含量的升高,稳定组织内源性SOD的活力,同时血浆溶酶休酶的释放减少,休克动物血压升高,死亡率下降,平均存活时间明显延长。实验结果尚表明,应用自由基清除酶(剂)可以明显减轻肠系膜上动脉夹闭(superior mcsenteric artery occlusion, SMAO)休克大鼠小肠粘膜的病理改变。
The rats were fasted for 1h after clamping the superior mesenteric artery of rats. Superoxide dismutasv (SOD), catalase (CAT), allopurinol (ALLO) and superoxide dismutase (SOD) + CAT, SOD + ALLO and SOD + CAT + ALLO. The results showed that in addition to CAT alone, the others alone or with free radical scavenging enzymes (agents) have anti-lipid peroxidation injury effect, the performance of the application of free radical scavenging enzyme (agent) can significantly inhibit the intestine, heart, liver , The content of malondialdehyde (MDA) in lung tissue was increased, the activity of endogenous SOD was also stabilized, and the release of plasminogenase was reduced. The blood pressure of shocked animals was decreased, the mortality was decreased, and the average survival time was significantly extend. The experimental results also show that the use of free radical scavenging enzyme (agent) can significantly reduce the pathological changes of small intestinal mucosa in rats with superior mesenteric artery occlusion (SMAO) shock.