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目的探讨血清肿瘤坏死因子-α(tumornecrosisfactor-α,TNF-α)水平测定在创伤性全身炎症反应综合征(systemicinflammatoryresponsesyndrome,SIRS)患者中的临床意义。方法用放射免疫学方法测定50例创伤性SIRS患者血清TNF-α的动态变化并与创伤非SIRS患者及正常对照组进行比较。结果创伤性SIRS患者血清TNF-α含量明显增高,峰值出现在第1天,TNF-α持续升高的患者预后不良。结论TNF-α参与了创伤性SIRS的病理过程,对创伤性SIRS患者测定血清TNF-α有助于判断疾病的转归及预后。
Objective To investigate the clinical significance of serum tumor necrosis factor-α (TNF-α) levels in patients with traumatic systemic inflammatory response syndrome (SIRS). Methods The dynamic changes of serum TNF-α in 50 patients with traumatic SIRS were measured by radioimmunoassay and compared with those of non-SIRS patients and normal controls. Results Serum TNF-α levels were significantly increased in patients with traumatic SIRS. The peak appeared on the first day, and the patients with persistent elevated TNF-α had a poor prognosis. Conclusions TNF-α participates in the pathological process of traumatic SIRS, and the determination of serum TNF-α in patients with traumatic SIRS can help to judge the outcome and prognosis of the disease.