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目的 :制备卟恶丙嗪分散片 ,并将其与另两种市售片剂的溶出度进行比较。方法 :通过实验获得处方和工艺 ,制定质量标准和溶出度测定方法 ,并对其进行质量评价和溶出度比较。结果 :本品完全符合英国药典中有关分散片的要求 ,其溶出参数 (m =0 .5 7,t50 =0 .5 1min ,td=0 .97min)与另两种市售片剂间差异存在极显著性。结论 :卟恶丙嗪分散片比另两种市售片剂崩解快、分散均匀度好、溶出快而完全。
OBJECTIVE: To prepare porrapropoxazine dispersible tablets and compare them with the dissolution of two other commercially available tablets. Methods: Prescription and technology were obtained through experiments, and the quality standard and the method of determination of dissolution were established, and their quality evaluation and dissolution were compared. Results: This product is in full compliance with the requirements of the relevant British Pharmacopoeia dispersible tablets, the dissolution parameters (m = 0.57, t50 = 0.51min, td = 0.97min) and the other two kinds of tablets there is a difference between the commercial Very significant. Conclusion: Porphyroxipram dispersible tablet disintegrated faster than the other two commercially available tablets, with good dispersion and fast and complete dissolution.