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蝙蝠葛碱(Dauricine山豆根碱)具有降压和抗实验性心律失常作用。猫乳头肌的研究表明,蝙蝠葛碱可降低心室肌的收缩性、自律性、兴奋性,延长不应期;认为其抗心律失常作用与不应期的延长,自律性和兴奋性的降低有关。本文在离体家兔心房,观察了蝙蝠葛碱对左房生理特性及右房频率的影响。 一、材料和方法 家兔1.5～2.5公斤,按Levy法制备离体左房和右房标本。实验在含Krebs-Henseleit液的10毫升恒温(31±1℃)浴槽中进行,持续通95％O_2
Dauricine (Dauricine) has antihypertensive and antiarrhythmic effects. Studies of cat papillary muscles have shown that dauricine reduces contractility, autonomy, and excitability of ventricular muscles and prolongs the refractory period; it is thought that antiarrhythmic effects are associated with prolonged refractory periods, decreased autoregulation and excitability. . In this paper, the effects of dauricine on the physiological characteristics of the left atrium and the frequency of the right atrium were observed in isolated rabbit atrium. First, materials and methods Rabbits 1.5 to 2.5 kg, according to the Levy method to prepare isolated left and right atrial specimens. The experiment was carried out in a 10 ml thermostatic (31±1°C) bath containing Krebs-Henseleit solution, and the continuous passage of 95% O 2