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目的研究恩拉霉素在XAD-16大孔树脂上吸附的动力学和热力学特性。方法通过静态吸附实验,利用实验数据对相关等温模型进行拟合来描述XAD-16大孔树脂对恩拉霉素的等温吸附行为;用热力学参数对恩拉霉素吸附过程的热力学性质进行描述;分别采用准一级动力学方程和准二级动力学方程探讨XAD-16大孔树脂吸附恩拉霉素的动力学特性。结果在298~308 K内,Freundlich模型能较好的描述XAD-16大孔树脂对恩拉霉素的吸附等温过程;ΔH<0,ΔG<0,恩拉霉素在XAD-16大孔树脂上的吸附属于自发的物理吸附过程;XAD-16大孔树脂对恩拉霉素吸附过程符合准二级动力学方程。结论通过对恩拉霉素在XAD-16大孔树脂上吸附热力学和动力学的研究,为XAD-16大孔树脂大规模分离纯化恩拉霉素提供了理论依据。
Objective To study the kinetics and thermodynamics of noramycin adsorption on XAD-16 macroporous resin. Methods The adsorption isotherm of XAD-16 macroporous resin to noramycin was described by the static adsorption experiment and the experimental data were used to fit the isothermal model. The thermodynamic properties of noramycin adsorption process were described by thermodynamic parameters. Quasi-first-order kinetic equation and quasi-second-order kinetic equation were respectively used to investigate the kinetics of the adsorption of enramycin by XAD-16 macroporous resin. Results In the range of 298K to 308K, Freundlich model can describe the adsorption isothermal process of noramycin by XAD-16 macroporous resin better. ΔH <0, ΔG <0, Adsorption on spontaneous physical adsorption process; XAD-16 macroporous resin adsorption of nymphithromycin standard pseudo-second-order kinetic equation. Conclusion The study on thermodynamics and kinetics of the adsorption of enramycin on XAD-16 macroporous resin provides a theoretical basis for the large-scale separation and purification of enramycin by XAD-16 macroporous resin.