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异戊巴比妥是常用的催眠镇静药物,治疗剂量下的药物动力学参数已有报道,而服用致死量甚至超致死量后的药物动力学参数究竟如何尚未见报道。我们曾收治一例口服异戊巴比妥约10g的病人,作了病人血浆中药物的定性定量工作,迅速判明了药物的中毒种类和数量,指导了临床救治用药,有效地抢救了病人。一、病人的一般情况曹某,女性,22岁,工人,健康,无特殊病史。3月26日午夜左右,家人发现其面色异常,呼之不应而急诊入院。门诊给予吸氧、气管插管、输液加洛贝林、可拉明后,
Amylin is a commonly used hypnotic sedative drug. The pharmacokinetic parameters at the therapeutic dose have been reported. However, the pharmacokinetic parameters after the lethal dose or even the lethal dose have not been reported yet. We have received a case of oral administration of about 10g of pentobarbital patients, made qualitative and quantitative analysis of the drug in the plasma of patients, quickly identified the type and quantity of poisoning drugs, guiding the clinical treatment of drugs, the effective rescue of patients. First, the general situation of the patient Cao, female, 22 years old, workers, health, no special history. Around midnight on March 26, his family members found that they were looking abnormal and should not be called for an emergency visit. Outpatient to give oxygen, endotracheal intubation, infusion of Gallobene, Clarine,